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To solve the problems of system efficiency lag and data privacy leakage in the process of health data collection, transmission and management, this paper designs a personal health information management and privacy protection system based on ZigBee based on the principles of practicality and security. The system is divided into perception layer, transmission layer and application layer. The system includes data acquisition, data transmission and data processing and analysis modules. While realizing real-time monitoring and analysis and management of personal physical data, it uses ZigBee wireless transmission technology to effectively guarantee Data privacy and security. Also, the RSA encryption algorithm and distributed storage technology are used in the system design to ensure the safety of data transmission and storage. Experimental results show that the system has real-time and convenient management of personal health information, realizes the real-time monitoring function of personal health information, and provides ideas for effectively protecting user data privacy and security.