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The layout design is a key important work in the development of aerospace vehicle which associated with overall performance and key technical index of aerospace vehicle. Base on “five constraints”, “six requirements”, “ten process” of layout for aerospace vehicle , the system for layout rapid design is presented, which was validated by prototype system on a basis of CATIA VPM in digital environment. The engineering practice shows that the system could resolve problems of detailed design of outline , structure layout, instrument layout, mass property analysis and automatic adjustment and rapid integrated optimization for outline design during layout design, and realized the parametric design, materialization and visualization of outline, layout , equipment and mass property ,and dynamic analysis and evaluation of layout. This system can be used as reference for the layout design of other spacecraft.