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As we all know, coronary interventional therapy of coronary disease has advantages of obvious effect, less trauma and faster recovery. However, at present, there are no practical objects in clinical practice training and practice teaching of medical specialty, and they are also vulnerable to radiation damage at the same time. In this study we develop a virtual simulation system for coronary interventional therapy with computer simulation technology, which mainly include basic unit of interventional equipment for coronary heart disease, transparent human vascular model, radiation-free imitating DSA imaging system, and 3D animation learning software. User can not only restore the various operating procedures, techniques and techniques of interventional treatment of real coronary heart disease, has a strong sense of realism, with free X-ray radiation, safe and reliable. This system can also creatively use the home-made human model to carry out practical training in operation and training. It can be popularized and applied directly in the practice teaching of medical students, which filled the gaps in the field without lab equipment and subjects.