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Aiming at the problem that the detection of foreign Substances in the oral liquid of traditional Chinese medicine is static, this paper proposes a mobile inspection method based on machine vision for visible foreign Substances in traditional Chinese medicine oral liquid bottles. This method is to change the static immobile oral liquid bottle of the emergency stop camera detection, into the bottle in the horizontal direction of movement at the same time to complete the vertical direction of the spin emergency stop camera detection. To overcome the problem that continuous shooting picture of the bottle position changes to find the drug area . Based on the improved imaging system and the mechanical system, the test bottle is tested for impurity detection when the bottle is to be moved linearly in the side of the spin. Based on the improved region search method, it is proposed to improve the detection speed by using the continuous pixel search algorithm, and then use the front and rear triangular window algorithm to determine the detection area of the drug solution area to improve the detection precision, And the difference method is used for impurity detection. Experimental results show that this method can quickly and effectively detect foreign Substances, to improve the detection’s speed.