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Automatic samplers are now widely used in analytical instruments and equipments. In order to achieve more faster, efficient and intelligent injection, a liquid-phase automatic sampler system designed based on the traditional sampler and 3D printer control technology. Three-axis linkage technology used to position the sampler bottles. The optimization solution of acceleration and deceleration can ensure the stability of needle in the motor starting or stopping process and the positional accuracy. The using of touch screen can make the sampler used alone. It can enhance the capacity of human-computer interaction and can also support the 485 communication with ion chromatography equipments or other special analytical equipments. The operation prompt can prevent the user operation errors. The system used the dedicate control chip DRV8825 designing for bipolar motor as drive circuit. It can improve the overall structure and composition, optimize the control of the master and drive circuit. The sampler has the advantages of simple structure, convenient operation, wide application, high degree of automation and intelligence, low cost of the manufacturing and maintenance. The practical application tests show that the system has good stability. The overall system performance improved greatly, and reached the design requirement.