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A new effective fusion method based on image blocks was proposed for multi-focus images. Firstly, two source images were divided into equal number of blocks with the same size. Then each block of two source images was inspected to be determined whether it is a clear block or not by analyzing the match degree of the energy gradient of the corresponding images blocks of source images, in which the energy gradient operator was chosen as the focus measure and a threshold value was set for the match degree of energy gradients. Then the clear domains of source images were isolated while the other regions were deemed fuzzy. All pixels in clear domains would be directly used as the corresponding ones of the fused image instead of any kind of processing in order to retain the in-focus regions as much as possible. However, for fusing the fuzzy regions of source images, an image sequence was constituted which depends on which source image has a higher average gradient for each image block, in which the image sequence contains a blending function was constituted based on the energy gradients of the image blocks that was relative to the distance of this pixel to the center of each image block. Then the image sequence and blending function were used to construct the fused image domains, in which the fused pixel was actually a weighted sum of the corresponding pixels in the images sequence. The experimental results shows that the method proposed is the reliability and rationality of image fusion results.