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A multi-channel digitizer based on PXI Express bus is designed for high sampling rate and high resolution test requirements of various digital devices. The digitizer, widely used in the field of measurement and control, has high openness, flexibility and modularization. Combined with the digitizer development process faced by the key issues and solutions, the device driver, interface encapsulation and application software of digitizer are researched in this paper. Firstly, several key issues of KMDF device driver development are discussed, such as configuration space access, interrupts handling and DMA data transmission. Secondly, after analyzing the application requirements of digitizer, this paper introduces the three-tier architecture of software design scheme based on .Net platform. At last, the experiment results show that this system has good reliability, stability and achieves the expected technical requirement and performance index.