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Now the medical career, telemedicine as advanced science and technology application; patient scientific treatment monitoring concept; fast information age embodiment, is becoming a popular research direction of medical career. It relies on computer technology, communication technology and information processing technology as the basis, combined with medical activities, in today's medical career which has broad prospects for development. This paper is designed for intelligent remote monitoring system of large scale disease, from physiological data acquisition, intelligent terminal, IOCP network communications and database and monitoring software as a starting point for the design, implementation of doctor or patient families through monitoring software to realize real-time remote monitoring and monitoring using wireless communication network. The design requirements and design structure of the system are put forward, and the reliability of the system in practical application and the completion degree of each requirement are observed through actual inspection. The results show that this system can accomplish remote real-time monitoring and intelligent demand for large patients.