Through the research and analysis of the time series monitoring method of the engine, a PXI bus based multi-channel sequential detection circuit system is designed. The hardware and software structure and functions of the system are introduced. The input circuit, digital circuits, FIFO memory circuit and PXI bus interface circuit are designed. The time series monitoring circuit system has been applied in the ground test and launch control system of missile and rocket launching, and it has been verified by the test of many times on the launching field, and achieved the expected results.