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Electrochemical sensor for detecting and tracking applied to feature substances in the body is facing the intelligence and integration problems, this paper puts forward a kind of electrochemical sensor for real-time data support system on chip based on automatic detection. First of all, will be applied to the structure, electrochemical sensor, the measured samples, detection, and detection of multi electrode solution interface transmitter unit integration in system on chip, combined with the signal conversion and power device, to achieve independent computation, storage and communication function of electrochemical sensors. Then, through the realization of the object to be measured, the test solution of multi electrode and collaborative SCM control logic calculation to meet the demand of automatic detection. Finally, data integration and automation design based on electrochemical sensor to support real-time data detection. Test results show that, the proposed scheme is superior to the traditional data detection divice.