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A set of temperature measurement points must be arranged on the cryopumps of neutral beam injector (NBI) for the purpose of monitoring their status. A kind of multi-channel low temperature measurement system is designed to meet the demand of NBI which could support multiple temperature sensors. 24-bit sigma-delta (Σ-Δ) analog-to-digital converter (ADC) AD7193 is adopted to perform analog-to-digital conversion. An ARM processor STM32F103ZET6 is used for setting the value of constant current source, switching different channels, controlling ADC, sending the data to the Ethernet by using TCP/IP protocol, RS232 data communication, data processing and controlling some other parts of the circuit. The circuit can be applied in low temperature measurement field which adopts four-wire temperature sensors driven by constant currents.