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To solve the problems in traditional domestic surveillance system including high cost, poor mobility, difficulty wiring and so on, a domestic mobile surveillance system based on ZigBee and Android was designed and realized. The system was with a layered architecture. The first layer was detection terminal with STM32 microprocessor core, including multiple physiological data collection nodes. The second layer was home gateway, including main node on ZigBee and the server computer. The gateway realized network communication between the server and detection terminal by wireless network technology of ZigBee. The third layer was Android mobile platform, which accessed the server with external network to provide an platform for remote interaction. This system is used in domestic health monitoring to the elderly. Two important physiological indexes, blood pressure and body temperature, are measured. The experiments show that this system has good communication quality, can achieve the collection, transmission and waveform display of physiological data, also the analysis and danger warning of blood pressure and body temperature, which meets the requirements of the domestic mobile monitoring.