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Non-rigid registration is an important research direction of medical image processing. For Demons derived from a series of classic registration algorithms on the computational complexity of medical imaging applications,the direction of the problem of lack of information were studied. Demons algorithm based on optical flow field model is dependent on the image gray gradient image is deformed when the lack of gradient information,the force can not be determined,and thus likely to cause the error,and the algorithm is only suitable for single-mode image registration. Therefore,we propose a frequency-domain Demons registration processing method based on wavelet transform theory(B-Demons). The method uses the wavelet transform can realize the benefits of better positioning on each scale,orientation and location information of the image reflected characteristics by the high frequency,low frequency of image transformation. Experimental results show that the algorithm is effective and robust.