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Human-Computer Interface(HCI) technology based on bioelectricity, which is a supplement to conventional HCI methods, has a broad application prospects. In order to achieve multi-user wireless information interaction in bioelectrical HCI system, an information interaction system based on ZigBee technology was proposed in this paper. The system was composed of ZigBee wireless communication module, information generation/procession module and serial communication module. Furthermore, EOG signals were used to generate interactive information by automatic detecting and coding. Effective EOG signal detection rate was more than 95%, and the transmission distance could reach 70 m without router and without shading and blocking under laboratory environment. Experimental results show that this system has the advantages of low power consumption, good stability, strong expansibility, easy to use and great practical value.