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This article has designed a remote health monitoring system based on GPS and GPRS to monitor the position and vital signs information of people who have health hazards. On the basis of STM32 and according to signal features of vital signs information sensors, the drive circuit of monitoring node has been designed. By using GPS and GPRS network, the software of monitoring node has been designed. Various monitoring terminals and data processing service platform are designed by using software design technology. Finally, this system can obtain and retransmit blood-oxygen signals, ECG, temperature and position information of body. Data processing service platform is responsible for information storage, analysis and dissemination.Various monitoring terminals can query data processing service platform for position and vital signs information. The test results show that this system can collect precise data, have strong ability to retransmit signals and meet the application requirements. 