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To design and analyze an automatic drip rate control system on intravenous infusion process, this paper carried out researches on system modeling and simulation. A static model of the process, which was then used to calculate a nonlinear dynamic model, was obtained by experimental data after curve fitting. A first-order inertial element was utilized to depict the dynamics of the control element, while the infrared-photoelectric-based drip rate detection element was represented by a definite integral model. The process model was approximately linearized on quiescent operating points by incremental method, then a PID control law was designed for the case of small setting value changes while an open-loop-ahead closed loop strategy was presented for the case of large setting value changes. The simulation results showed the presented model could reflect the actual characteristics of the controlled process and control system, which was a good reference to implementation of the control system.